Phenylalanine and its toxic derivatives accumulate within the body and might trigger mind damage with psychological retardation, unexpectedly fair hair, blue eyes and a musty body odour. The disease is bro

Phenylalanine and its toxic derivatives accumulate within the body and might trigger mind damage with psychological retardation, unexpectedly fair hair, blue eyes and a musty body odour. The disease is brought on by a few of more than 500 mutations of the gene that codes for phenylalanine hydroxylase. A co-factor, tetrahydrobiopterin can be concerned in the conversion and it has been discovered that in gentle circumstances of phenylketonuria this substance can significantly decrease the blood ranges of phenylalanine.